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Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2014 Mar; Vol. 35 (3), pp. 146-54. Date of Electronic Publication: 2014 Jan 16. - Publication Year :
- 2014
-
Abstract
- Recent studies in mice have identified single molecules that can delay multiple diseases of aging and extend lifespan. In theory, such molecules could prevent dozens of diseases simultaneously, potentially extending healthy years of life. In this review, we discuss recent advances, controversies, opportunities, and challenges surrounding the development of SIRT1 activators, molecules with the potential to delay aging and age-related diseases. Sirtuins comprise a family of NAD⁺-dependent deacylases that are central to the body's response to diet and exercise. New studies indicate that both natural and synthetic sirtuin activating compounds (STACs) work via a common allosteric mechanism to stimulate sirtuin activity, thereby conferring broad health benefits in rodents, primates, and possibly humans. The fact that two-thirds of people in the USA who consume multiple dietary supplements consume resveratrol, a SIRT1 activator, underscores the importance of understanding the biochemical mechanism, physiological effects, and safety of STACs.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Aging metabolism
Aging pathology
Animals
Cardiovascular Diseases drug therapy
Cardiovascular Diseases metabolism
Diabetes Mellitus drug therapy
Diabetes Mellitus metabolism
Humans
Inflammation drug therapy
Inflammation metabolism
Longevity drug effects
Longevity physiology
Molecular Targeted Therapy
Neoplasms drug therapy
Neoplasms metabolism
Aging drug effects
Sirtuin 1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3735
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24439680
- Full Text :
- https://doi.org/10.1016/j.tips.2013.12.004