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Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.
- Source :
-
Leukemia research [Leuk Res] 2014 Apr; Vol. 38 (4), pp. 443-6. Date of Electronic Publication: 2013 Dec 25. - Publication Year :
- 2014
-
Abstract
- For patients with acute myeloid leukemia from antecedent myelodysplastic syndrome particularly after azanucleoside treatment failure, outcome is poor. Here, we conducted a case-control study in these patients to compare the efficacy of CLAG-M induction (28 patients) versus standard 3+7 induction chemotherapy (24 patients). Response rates (P=0.014) and median overall survival (P=0.025) were 64% and 202 days (95% CI 37-367 days) versus 29% and 86 days (95% CI 36-136) in the CLAG-M and 3+7 cohorts, respectively. Median overall survival was 202 (95% CI 37-367 days) versus 86 days (95% CI 36-136) (P=0.025), respectively. CLAG-M has encouraging activity in this patient group.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Case-Control Studies
Chemotherapy, Adjuvant adverse effects
Chemotherapy, Adjuvant standards
Cladribine
Cytarabine
Disease Progression
Drug Resistance, Neoplasm drug effects
Female
Filgrastim
Granulocyte Colony-Stimulating Factor adverse effects
Humans
Induction Chemotherapy adverse effects
Induction Chemotherapy standards
Leukemia, Myeloid, Acute mortality
Leukemia, Myeloid, Acute pathology
Male
Middle Aged
Mitoxantrone adverse effects
Myelodysplastic Syndromes pathology
Recombinant Proteins administration & dosage
Recombinant Proteins adverse effects
Treatment Failure
Young Adult
Antineoplastic Combined Chemotherapy Protocols
Azacitidine therapeutic use
Granulocyte Colony-Stimulating Factor administration & dosage
Leukemia, Myeloid, Acute drug therapy
Mitoxantrone administration & dosage
Myelodysplastic Syndromes drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5835
- Volume :
- 38
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Leukemia research
- Publication Type :
- Academic Journal
- Accession number :
- 24439565
- Full Text :
- https://doi.org/10.1016/j.leukres.2013.12.010