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A new strategy to construct acyclic nucleosides via Ag(I)-catalyzed addition of pronucleophiles to 9-allenyl-9H-purines.
- Source :
-
Organic letters [Org Lett] 2014 Feb 07; Vol. 16 (3), pp. 900-3. Date of Electronic Publication: 2014 Jan 17. - Publication Year :
- 2014
-
Abstract
- A new strategy to construct acyclic nucleosides with diverse side chains was developed. With Ag(I) salts as catalysts, the hydrocarboxylation, hydroamination, and hydrocarbonation reactions proceeded well, affording acyclic nucleosides in good yields (41 examples, 60-98% yields). Meanwhile, these reactions exhibited high chemoselectivities and E-selectivities.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 24437554
- Full Text :
- https://doi.org/10.1021/ol4036566