Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy.

Authors :: López-Noriega A
Hastings CL
Ozbakir B
O'Donnell KE
O'Brien FJ
Storm G
Hennink WE
Duffy GP
Ruiz-Hernández E
Source :: Advanced healthcare materials [Adv Healthc Mater] 2014 Jun; Vol. 3 (6), pp. 854-9. Date of Electronic Publication: 2014 Jan 16.
Publication Year :: 2014
Abstract: A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Cell Line, Tumor
Cell Survival drug effects
Chitosan chemistry
Doxorubicin chemistry
Doxorubicin metabolism
Doxorubicin pharmacology
Glycerophosphates chemistry
Humans
Temperature
Hydrogel, Polyethylene Glycol Dimethacrylate chemistry
Liposomes chemistry

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