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A sulfhydryl-rich IgM protein with multiple serological specificities.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 1987 Jul; Vol. 69 (1), pp. 148-56. - Publication Year :
- 1987
-
Abstract
- A monoclonal IgM lambda protein from a patient (E.T.) suffering from a lymphocytic lymphoma agglutinated Salmonella typhi bacteria and uncoated acryl particles. The antigenic determinant on Salmonella typhi bacteria was found to be 0-12 (alpha-D-Galp-(1-2)-alpha-D-Manp) while the structure on acryl particles recognized by IgM ET has not been defined. Both binding sites for bacteria and acryl particle determinants are localized on the same IgM molecule. The uncommon affinity of this IgM protein for some divalent heavy metal ions led to the finding of an unusually high content of sulfhydryl groups in the Fab portion of the molecule.
- Subjects :
- Acrylates immunology
Aged
Agglutination Tests
Amino Acids analysis
Antibodies, Monoclonal immunology
Antibodies, Neoplasm immunology
Disaccharides immunology
Epitopes immunology
Female
Humans
Lipopolysaccharides immunology
Salmonella typhi immunology
Sulfhydryl Compounds analysis
Antibody Specificity
Immunoglobulin M immunology
Leukemia, Lymphocytic, Chronic, B-Cell immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 69
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 2443287