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Clinical impact of women with gestational diabetes mellitus by the new consensus criteria: two year experience in a single institution in Japan.
- Source :
-
Endocrine journal [Endocr J] 2014; Vol. 61 (4), pp. 353-8. Date of Electronic Publication: 2014 Jan 16. - Publication Year :
- 2014
-
Abstract
- There is a paucity of information on perinatal data regarding gestational diabetes mellitus (GDM) by the new criteria from a real experience because the number of health care associations implementing the new criteria is still limited. The aim of this study is to investigate perinatal features of the new criteria-defined GDM. We reviewed a total of 995 women with singleton pregnancy that underwent GDM screening followed by a diagnostic oral glucose tolerance test (OGTT). All women found to have GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. Of the 995 women, 141 had GDM (14.2%): 104 with one, 27 with two, and 10 with three abnormal OGTT values. Women with two or three abnormal OGTT values (2/3-AV) needed insulin treatment more frequently than those with one abnormal OGTT value (1-AV) (70.3% vs 23.1%, P < 0.0001). After adjustment for age, pregravid overweight, gestational weeks at diagnosis, a first-degree family history of diabetes was correlated with the implementation of insulin treatment in women with 1-AV (adjusted odds ratio 3.9; 95% Confidence Interval 1.7-9.2; P = 0.001). When compared perinatal outcomes between women with normal glucose tolerance and GDM, fetal growth and the occurrence of pregnancy-induced hypertension were comparable between the two groups. Our data suggest that the IADPSG-defined GDM with 1-AV show less severe glucose intolerance, but might be at risk of insulin requirement when a first-degree family history of diabetes exists.
- Subjects :
- Adult
Cohort Studies
Combined Modality Therapy
Consensus
Diabetes, Gestational blood
Diabetes, Gestational physiopathology
Diabetes, Gestational therapy
Family Health
Female
Glucose Tolerance Test
Hospitals, University
Humans
International Agencies
Japan
Pregnancy
Pregnancy Complications etiology
Pregnancy Trimester, First
Pregnancy in Diabetics blood
Pregnancy in Diabetics diagnosis
Pregnancy in Diabetics physiopathology
Pregnancy in Diabetics therapy
Retrospective Studies
Diabetes, Gestational diagnosis
Diet, Diabetic
Hypoglycemic Agents therapeutic use
Insulin therapeutic use
Practice Guidelines as Topic
Pregnancy Complications prevention & control
Prenatal Diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1348-4540
- Volume :
- 61
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Endocrine journal
- Publication Type :
- Academic Journal
- Accession number :
- 24430729
- Full Text :
- https://doi.org/10.1507/endocrj.ej13-0496