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The 5-year incidence of bleb-related infection and its risk factors after filtering surgeries with adjunctive mitomycin C: collaborative bleb-related infection incidence and treatment study 2.
- Source :
-
Ophthalmology [Ophthalmology] 2014 May; Vol. 121 (5), pp. 1001-6. Date of Electronic Publication: 2014 Jan 11. - Publication Year :
- 2014
-
Abstract
- Purpose: To report the 5-year incidence of bleb-related infection after mitomycin C-augmented glaucoma filtering surgery and to investigate the risk factors for infections.<br />Design: Prospective, observational cohort study.<br />Participants: A total of 1098 eyes of 1098 glaucoma patients who had undergone mitomycin C-augmented trabeculectomy or trabeculectomy combined with phacoemulsification and intraocular lens implantation performed at 34 clinical centers.<br />Methods: Patients were followed up at 6-month intervals for 5 years, with special attention given to bleb-related infections. The follow-up data were analyzed via Kaplan-Meier survival analysis and the Cox proportional hazards model.<br />Main Outcome Measures: Incidence of bleb-related infection over 5 years and risk factors for infections.<br />Results: Of the 1098 eyes, a bleb-related infection developed in 21 eyes. Kaplan-Meier survival analysis revealed that the incidence of bleb-related infection was 2.2±0.5% (cumulative incidence ± standard error) at the 5-year follow-up for all cases, whereas it was 7.9±3.1% and 1.7±0.4% for cases with and without a history of bleb leakage, respectively (P = 0.000, log-rank test). When only eyes with a well-functioning bleb were counted, it was 3.9±1.0%. No differences were found between the trabeculectomy cases and the combined surgery cases (P = 0.398, log-rank test) or between cases with a fornix-based flap and those with a limbal-based flap (P = 0.651, log-rank test). The Cox model revealed that a history of bleb leakage and younger age were risk factors for infections.<br />Conclusions: The 5-year cumulative incidence of bleb-related infection was 2.2±0.5% in eyes treated with mitomycin C-augmented trabeculectomy or trabeculectomy combined with phacoemulsification and intraocular lens implantation in our prospective, multicenter study. Bleb leakage and younger age were the main risk factors for infections.<br /> (Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents therapeutic use
Cohort Studies
Combined Modality Therapy
Eye Infections, Bacterial drug therapy
Eye Infections, Bacterial microbiology
Female
Glaucoma classification
Humans
Incidence
Kaplan-Meier Estimate
Lens Implantation, Intraocular
Male
Middle Aged
Phacoemulsification
Prognosis
Prospective Studies
Risk Factors
Surgical Wound Infection drug therapy
Surgical Wound Infection microbiology
Young Adult
Alkylating Agents administration & dosage
Eye Infections, Bacterial epidemiology
Glaucoma surgery
Mitomycin administration & dosage
Surgical Wound Infection epidemiology
Surgically-Created Structures
Trabeculectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1549-4713
- Volume :
- 121
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 24424248
- Full Text :
- https://doi.org/10.1016/j.ophtha.2013.11.025