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Cardiorespiratory effects induced by 2-nitrate-1,3-dibuthoxypropan are reduced by nitric oxide scavenger in rats.
- Source :
-
Autonomic neuroscience : basic & clinical [Auton Neurosci] 2014 Apr; Vol. 181, pp. 31-6. Date of Electronic Publication: 2013 Dec 24. - Publication Year :
- 2014
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Abstract
- The search for new nitric oxide donors is warranted by the limitations of organic nitrates currently used in cardiology. The new organic nitrate 2-nitrate-1,3-dibuthoxypropan (NDBP) exhibited promising cardiovascular activities in previous studies. The aim of this study was to investigate the cardiorespiratory responses evoked by NDBP and to compare them to the clinically used organic nitrate nitroglycerine (NTG). Arterial pressure, heart rate and respiration were recorded in conscious adult male Wistar rats. Bolus i.v. injection of NDBP (1 to 15mg/kg; n=8) and NTG (0.1 to 5mg/kg; n=8) produced hypotension. NDBP induced bradycardia at all doses, while NTG induced tachycardia at three lower doses but bradycardia at higher doses. Hydroxocobalamin (20mg/kg; HDX), a NO scavenger, blunted hypotension induced by NDBP (15mg/kg), and its bradycardic effect (n=6). In addition, HDX blunted both hypotension and bradycardia induced by a single dose of NTG (2.5mg/kg; n=6). Both NDBP and NTG altered respiratory rate, inducing a biphasic effect with a bradypnea followed by a tachypnea; HDX attenuated these responses. Our data indicate that NDBP and NTG induce hypotension, bradycardia and bradypnea, which are mediated by nitric oxide release.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Arterial Pressure physiology
Bradycardia chemically induced
Bradycardia drug therapy
Bradycardia physiopathology
Cardiovascular Agents administration & dosage
Consciousness
Dose-Response Relationship, Drug
Heart Rate physiology
Hydroxocobalamin pharmacology
Hypotension chemically induced
Hypotension drug therapy
Hypotension physiopathology
Male
Nitrates administration & dosage
Nitric Oxide metabolism
Nitroglycerin administration & dosage
Nitroglycerin pharmacology
Propane administration & dosage
Propane pharmacology
Rats
Rats, Wistar
Tachypnea chemically induced
Tachypnea drug therapy
Tachypnea physiopathology
Vasodilator Agents administration & dosage
Vasodilator Agents pharmacology
Arterial Pressure drug effects
Cardiovascular Agents pharmacology
Heart Rate drug effects
Nitrates pharmacology
Propane analogs & derivatives
Respiration drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7484
- Volume :
- 181
- Database :
- MEDLINE
- Journal :
- Autonomic neuroscience : basic & clinical
- Publication Type :
- Academic Journal
- Accession number :
- 24418115
- Full Text :
- https://doi.org/10.1016/j.autneu.2013.12.012