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Old World hantaviruses: aspects of pathogenesis and clinical course of acute renal failure.

Authors :
Krautkrämer E
Zeier M
Source :
Virus research [Virus Res] 2014 Jul 17; Vol. 187, pp. 59-64. Date of Electronic Publication: 2014 Jan 08.
Publication Year :
2014

Abstract

Hantavirus-associated diseases represent emerging infections that are ranked in the highest priority group of communicable diseases for surveillance and epidemiological research. In the last years, several novel hantavirus species were described and the number of host reservoir species harboring hantaviruses is also increasing. Reports of cases with severe or atypical clinical courses become also more frequent. These facts raise more and more questions concerning host reservoir specificity, pathogenicity and molecular mechanism of pathogenesis. Hantavirus disease is characterized by vascular leakage due to increased capillary permeability. The infection manifests often in the lung (hantaviral cardiopulmonary syndrome; HCPS) or in the kidney (hemorrhagic fever with renal syndrome, HFRS). The underlying mechanisms of both syndromes are probably similar despite the difference in organ tropism. Characterization of hantaviral replication cycle and of patient-specific determinants will help to identify factors responsible for the clinical symptoms and course.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-7492
Volume :
187
Database :
MEDLINE
Journal :
Virus research
Publication Type :
Academic Journal
Accession number :
24412712
Full Text :
https://doi.org/10.1016/j.virusres.2013.12.043