The function of BAFF on T helper cells in autoimmunity.

Authors :: Chen M
Lin X
Liu Y
Li Q
Deng Y
Liu Z
Brand D
Guo Z
He X
Ryffel B
Zheng SG
Source :: Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2014 Jun; Vol. 25 (3), pp. 301-5. Date of Electronic Publication: 2013 Dec 24.
Publication Year :: 2014
Abstract: B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)