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In vitro maturation of oocytes is not a risk factor for adult metabolic syndrome of mouse offspring.
- Source :
-
European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2014 Mar; Vol. 174, pp. 96-9. Date of Electronic Publication: 2013 Dec 17. - Publication Year :
- 2014
-
Abstract
- Objective: To evaluate the effect of in vitro maturation (IVM) of oocytes on the serum cholesterol profile, glucose and insulin tolerance, blood pressure, and heart rate of adult mouse offspring.<br />Study Design: The serum cholesterol profile, glucose and insulin tolerance, blood pressure, and heart rate of adult offspring born from in vitro matured oocytes were compared with those of adult offspring born from in vivo matured oocytes.<br />Results: Offspring born from in vitro matured oocytes showed a normal serum cholesterol profile. In the glucose tolerance test, glucose levels were consistently elevated in adult offspring born from in vitro matured oocytes compared with those born from in vivo matured oocytes, but the differences did not reach statistical significance. There were no significant differences in insulin tolerance, blood pressure, and heart rate between adult offspring born from in vitro matured oocytes and those from in vivo matured oocytes.<br />Conclusion: No alterations were found in the metabolism profile of adult mouse offspring born from in vitro matured oocytes compared with that from in vivo matured oocytes.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Blood Glucose analysis
Blood Pressure
Cells, Cultured
Cholesterol blood
Embryo Transfer
Female
Glucose Tolerance Test
Heart Rate
Insulin blood
Lipids blood
Male
Metabolic Syndrome blood
Mice
Mice, Inbred C57BL
Risk Factors
Sex Factors
Fertilization in Vitro methods
In Vitro Oocyte Maturation Techniques
Metabolic Syndrome etiology
Oocytes growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7654
- Volume :
- 174
- Database :
- MEDLINE
- Journal :
- European journal of obstetrics, gynecology, and reproductive biology
- Publication Type :
- Academic Journal
- Accession number :
- 24405727
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2013.12.016