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Induced marine fungus Chondrostereum sp. as a means of producing new sesquiterpenoids chondrosterins I and J by using glycerol as the carbon source.
- Source :
-
Marine drugs [Mar Drugs] 2014 Jan 07; Vol. 12 (1), pp. 167-75. Date of Electronic Publication: 2014 Jan 07. - Publication Year :
- 2014
-
Abstract
- Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM.
- Subjects :
- Antineoplastic Agents chemistry
Cell Line, Tumor
Chromatography, High Pressure Liquid
Circular Dichroism
Crystallography, X-Ray
Culture Media
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Models, Molecular
Polyporaceae chemistry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tetrazolium Salts
Thiazoles
Glycerol metabolism
Polyporaceae metabolism
Sesquiterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 24402176
- Full Text :
- https://doi.org/10.3390/md12010167