Back to Search
Start Over
Newborn LpL (Ser447Stop, Asn291Ser) genotypes and the interaction with maternal genotypes influence the risk for different types of preeclampsia: modulating effect on lipid profile and pregnancy outcome.
- Source :
-
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2014 Mar; Vol. 30 (3), pp. 221-5. Date of Electronic Publication: 2014 Jan 08. - Publication Year :
- 2014
-
Abstract
- Aim: To establish that newborn Ser447Stop and Asn291Ser may have interactive effects with maternal genotypes on the plasma lipoprotein levels, risk of preeclampsia as well as on the prognosis of preeclampsia.<br />Materials and Methods: Seventy preeclamptic women and 94 normotensive pregnant women, and their newborns were genotyped using PCR-RFLP methods.<br />Results: The risk of mild and severe preeclampsia was 4 (p = 0.004) and 5.18 (p = 0.001), respectively, if both the mother and newborn were carriers of the Ser447/Ser477 genotype. If both the mother and newborn were carriers of the Asn291Ser variant, the risk to develop severe preeclampsia was 6.07 (p = 0.03). Women with mild and severe preeclampsia had higher TG (p < 0.001; p < 0.001) and LDL-C levels (p = 0.008; p < 0.001) if both the mother and newborn were carriers of the Ser447/Ser447 genotype. Women with severe preeclampsia had significantly higher TG (p = 0.03) and LDL-C levels (p = 0.037) if both the mother and newborn were carriers of Asn291Ser. Newborn/maternal LpL interaction had no statistically significant influence on pregnancy outcome.<br />Conclusions: The newborn/maternal LpL interaction influences the severity of preeclampsia and modulates the lipid profile particularly in severe preeclampsia.
- Subjects :
- Adult
Amino Acid Substitution
Cholesterol, HDL blood
Cholesterol, LDL blood
Codon, Terminator
Female
Genetic Association Studies
Heterozygote
Hospitals, University
Humans
Infant, Newborn
Lipoprotein Lipase blood
Male
Pre-Eclampsia blood
Pre-Eclampsia physiopathology
Pregnancy
Pregnancy Outcome
Romania
Severity of Illness Index
Triglycerides blood
Genetic Predisposition to Disease
Hyperlipidemias etiology
Lipoprotein Lipase genetics
Polymorphism, Genetic
Pre-Eclampsia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0766
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 24400599
- Full Text :
- https://doi.org/10.3109/09513590.2013.871512