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Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy.
- Source :
-
Journal of inflammation research [J Inflamm Res] 2013 Dec 27; Vol. 7, pp. 1-7. Date of Electronic Publication: 2013 Dec 27 (Print Publication: 2013). - Publication Year :
- 2013
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Abstract
- Purpose: The aim of the study reported here was to determine the effect of surgical menopause by bilateral salpingo-oophorectomy (BSO) on circulating levels of cytokines and chemokines related to the pathogenesis of atherosclerosis.<br />Patients and Methods: A total of 110 women were recruited for this study from the outpatient clinic of our facility. We divided the women into three groups: 1) women with a regular menstrual cycle, 2) women in whom less than 5 years had passed since their BSO, and 3) women in whom 5 years or more had passed since their BSO. Concentrations of nine cytokines and chemokines in serum were measured.<br />Results: The serum monocyte chemoattractant protein-1 (MCP-1) level in women in whom less than 5 years had passed since their BSO was significantly higher than in women with a regular menstrual cycle (P<0.05). There were significant differences in serum interleukin (IL)-7 among the three groups (P=0.035). MCP-1 showed a significant positive correlation (r=0.320, P=0.008) with follicle-stimulating hormone in women with a regular menstrual cycle and in women in whom less than 5 years had passed since their BSO.<br />Conclusion: A hypoestrogenic state due to BSO induced changes in MCP-1 and IL-7 levels. MCP-1 level showed a significant increase in the early period after BSO, while IL-7 level showed a significant decrease in the late period after BSO.
Details
- Language :
- English
- ISSN :
- 1178-7031
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of inflammation research
- Publication Type :
- Academic Journal
- Accession number :
- 24399882
- Full Text :
- https://doi.org/10.2147/JIR.S52728