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Effectiveness and safety of reduced-dose telaprevir-based triple therapy in chronic hepatitis C patients.
- Source :
-
Hepatology research : the official journal of the Japan Society of Hepatology [Hepatol Res] 2014 Oct; Vol. 44 (10), pp. E163-71. Date of Electronic Publication: 2014 Jan 08. - Publication Year :
- 2014
-
Abstract
- Aim: To compare the early virological effectiveness, sustained virological response and safety of telaprevir 1500 mg/day with telaprevir 2250 mg/day, when combined in triple therapy with pegylated interferon and ribavirin in Japanese patients with high viral loads of genotype 1 hepatitis C virus.<br />Methods: The telaprevir 2250 mg/day and 1500 mg/day groups each contained 60 patients matched by age, sex and history of previous interferon-based treatment. Serum levels of genotype 1 hepatitis C virus RNA, hemoglobin levels, drug adherence and drug discontinuation rates were monitored during and after triple therapy.<br />Results: Patients receiving telaprevir 1500 mg/day had significantly lower telaprevir adherence and lower initial ribavirin dose but similar or superior pegylated interferon and ribavirin adherence and a lower rate of telaprevir discontinuation than did those receiving telaprevir 2250 mg/day. The early virological responses and sustained virological response rates were similar in both groups. Hemoglobin levels decreased to a greater extent in patients treated with telaprevir 2250 mg/day.<br />Conclusion: Compared to triple therapy including telaprevir 2250 mg/day, that including telaprevir at a reduced dose of 1500 mg/day was associated with lower rates of anemia and similar antiviral efficacy. Such a regimen may meaningfully improve sustained virological response rates, especially among female and elderly Japanese patients.<br /> (© 2013 The Japan Society of Hepatology.)
Details
- Language :
- English
- ISSN :
- 1386-6346
- Volume :
- 44
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Hepatology research : the official journal of the Japan Society of Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 24397402
- Full Text :
- https://doi.org/10.1111/hepr.12268