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Multimodal SPION-CREKA peptide based agents for molecular imaging of microthrombus in a rat myocardial ischemia-reperfusion model.
- Source :
-
Biomaterials [Biomaterials] 2014 Mar; Vol. 35 (9), pp. 2961-70. Date of Electronic Publication: 2014 Jan 03. - Publication Year :
- 2014
-
Abstract
- Microthrombosis plays a key role in many cardiovascular diseases. Although it is not difficult to localize thrombus within large or middle-sized vessels, the noninvasive diagnostic regimen for the detection of microthrombus remains scarce. Here we developed a nanoagent by conjucting superparamagnetic iron-oxide nanoparticle with fluorophore and a targeting element, CREKA, a peptide with special affinity for fibrin. In a rat model of myocardial ischemia-reperfusion (MI/R), the multimodal nanoagents were readily and selectively accumulated within microthrombosis, which was detectable by both magnetic resonance and optical imaging modalities. The fibrin-targeted nanoagent could be expected to have utility not only in molecular imaging of fibrin, understanding the mechanisms of microcirculation disorders, but also in targeted therapy with fibrinolytic agents.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Blood Coagulation drug effects
Blood Platelets drug effects
Blood Platelets pathology
Blood Platelets ultrastructure
Disease Models, Animal
Humans
Male
Microscopy, Fluorescence
Myocardial Reperfusion Injury complications
Nanoparticles chemistry
Nanoparticles ultrastructure
Optical Imaging
Particle Size
Rats
Rats, Sprague-Dawley
Static Electricity
Dextrans
Magnetite Nanoparticles
Molecular Imaging methods
Multimodal Imaging methods
Myocardial Reperfusion Injury diagnosis
Oligopeptides pharmacology
Thrombosis complications
Thrombosis diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5905
- Volume :
- 35
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 24393265
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2013.12.038