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New biological treatments for gynecological tumors: focus on angiogenesis.
- Source :
-
Expert opinion on biological therapy [Expert Opin Biol Ther] 2014 Mar; Vol. 14 (3), pp. 337-46. Date of Electronic Publication: 2014 Jan 06. - Publication Year :
- 2014
-
Abstract
- Introduction: Gynecological tumors are a group of heterogeneous malignancies, with only modest results having been observed thus far with chemotherapy in advanced disease. New insights from pathobiology of these tumors have shed new light on potential new therapeutic targets. Angiogenesis is one of the most important processes involved in tumorigenesis, and effective treatments targeting the angiogenic machinery are now available.<br />Areas Covered: In this review, we will focus on angiogenesis as a therapeutic target in gynecological cancer patients. After a brief introduction on the angiogenesis machinery involvement in these malignancies, the most recent clinical data will be discussed.<br />Expert Opinion: Although clinical data with antiangiogenics are groundbreaking in several tumors such as ovarian epithelial cancer, overall efficacy of these agents is far from what was initially envisaged. As with other molecular targeted agents, selection of patients who may benefit from these agents will surely contribute to demonstrating better results. However, this does not diminish the clinical relevance of the above-mentioned results in a difficult field such as gynecological malignancies.
- Subjects :
- Angiogenesis Inhibitors pharmacology
Animals
Carcinoma, Ovarian Epithelial
Clinical Trials as Topic trends
Female
Humans
Neoplasms, Glandular and Epithelial diagnosis
Neoplasms, Glandular and Epithelial therapy
Ovarian Neoplasms diagnosis
Ovarian Neoplasms therapy
Treatment Outcome
Angiogenesis Inhibitors therapeutic use
Biological Products therapeutic use
Genital Neoplasms, Female diagnosis
Genital Neoplasms, Female therapy
Neovascularization, Pathologic diagnosis
Neovascularization, Pathologic drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7682
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Expert opinion on biological therapy
- Publication Type :
- Academic Journal
- Accession number :
- 24387684
- Full Text :
- https://doi.org/10.1517/14712598.2014.873401