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Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases.

Authors :
Rahal JA
Ishak RS
Otrock ZK
Maakaron JE
Ghosn S
Taher AT
Source :
Turkish journal of haematology : official journal of Turkish Society of Haematology [Turk J Haematol] 2013 Jun; Vol. 30 (2), pp. 184-7. Date of Electronic Publication: 2013 Jun 05.
Publication Year :
2013

Abstract

Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications.Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.

Details

Language :
English
ISSN :
1300-7777
Volume :
30
Issue :
2
Database :
MEDLINE
Journal :
Turkish journal of haematology : official journal of Turkish Society of Haematology
Publication Type :
Academic Journal
Accession number :
24385783
Full Text :
https://doi.org/10.4274/Tjh.2012.0134