MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter.

Authors :: Gnemmi V
Bouillez A
Gaudelot K
Hémon B
Ringot B
Pottier N
Glowacki F
Villers A
Vindrieux D
Cauffiez C
Van Seuningen I
Bernard D
Leroy X
Aubert S
Perrais M
Source :: Cancer letters [Cancer Lett] 2014 May 01; Vol. 346 (2), pp. 225-36. Date of Electronic Publication: 2013 Dec 30.
Publication Year :: 2014
Abstract: MUC1 is overexpressed in human carcinomas. The transcription factor SNAIL can activate epithelial-mesenchymal transition (EMT) in cancer cells. In this study, in renal carcinoma, we demonstrate that (i) MUC1 and SNAIL were overexpressed in human sarcomatoid carcinomas, (ii) SNAIL increased indirectly MUC1 expression, (iii) MUC1 overexpression induced EMT, (iv) MUC1 C-terminal domain (MUC1-C) and β-catenin increased SNAIL transcriptional activity by interaction with its promoter and (v) blocking MUC1-C nuclear localization decreased Wnt/β-catenin signaling pathway activation and SNAIL expression. Altogether, our findings demonstrate that MUC1 is an actor in EMT and appears as a new therapeutic target.<br /> (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)

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