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MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter.
- Source :
-
Cancer letters [Cancer Lett] 2014 May 01; Vol. 346 (2), pp. 225-36. Date of Electronic Publication: 2013 Dec 30. - Publication Year :
- 2014
-
Abstract
- MUC1 is overexpressed in human carcinomas. The transcription factor SNAIL can activate epithelial-mesenchymal transition (EMT) in cancer cells. In this study, in renal carcinoma, we demonstrate that (i) MUC1 and SNAIL were overexpressed in human sarcomatoid carcinomas, (ii) SNAIL increased indirectly MUC1 expression, (iii) MUC1 overexpression induced EMT, (iv) MUC1 C-terminal domain (MUC1-C) and β-catenin increased SNAIL transcriptional activity by interaction with its promoter and (v) blocking MUC1-C nuclear localization decreased Wnt/β-catenin signaling pathway activation and SNAIL expression. Altogether, our findings demonstrate that MUC1 is an actor in EMT and appears as a new therapeutic target.<br /> (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Carcinoma, Renal Cell genetics
Cell Line, Tumor
Cell Nucleus metabolism
Epithelial-Mesenchymal Transition
HEK293 Cells
Humans
Kidney Neoplasms genetics
Mucin-1 genetics
Promoter Regions, Genetic
RNA, Messenger biosynthesis
RNA, Messenger genetics
Snail Family Transcription Factors
Transcription Factors genetics
Transcriptional Activation
Up-Regulation
Wnt Signaling Pathway
Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell pathology
Kidney Neoplasms metabolism
Kidney Neoplasms pathology
Mucin-1 biosynthesis
Transcription Factors biosynthesis
Wnt Proteins metabolism
beta Catenin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 346
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 24384091
- Full Text :
- https://doi.org/10.1016/j.canlet.2013.12.029