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The investigation of specific biochemical markers in monitoring kidney function of drug addicts.
- Source :
-
Postepy higieny i medycyny doswiadczalnej (Online) [Postepy Hig Med Dosw (Online)] 2013 Dec 05; Vol. 67, pp. 1214-21. Date of Electronic Publication: 2013 Dec 05. - Publication Year :
- 2013
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Abstract
- Introduction: An increasingly important issue in the Polish population is drug abuse. It leads to extensive damage of parenchymal organs, including kidney. Establishing early markers of organ damage and their monitoring during rehabilitation therapy is therefore of pivotal importance. This study evaluated the utility of highly specific and selective markers (NGAL, IL-18, a and π-GST isoenzyme, and ß2-M). The influence of opioid drugs and other factors on kidney function (HIV and HCV infections, duration and the kind of drugs abused) was determined.<br />Materials and Methods: Urine collected from 83 subjects who abused drugs and 33 healthy volunteers was tested with ELISA using specific antibodies (IBL, Biotron, Bioporto-Diagnostics). HIV infection was confirmed with western-blotting and HCV with PCR. CD4 lymphocytes were quantified with flow cytometry. RFLP and PCR were used to determine the viral load of HIV and HCV (genotype).<br />Results: A significant increase of IL-18, NGAL and β2M activity in heroin addicts compared to the control group was noted as well as the influence of HIV infection on NGAL and β2M excretion. A statistically significant (p=0.04) correlation between the viral load and IL-18 concentration was noted while no significant influence of the duration and the kind of drugs abused, the route of intake or the age of addicts was seen. Only the NGAL concentration was sex dependent and significantly higher in women.<br />Discussion: This study showed the specific, clinical utility of IL-18, NGAL, and β2M in the evaluation of renal function in drug addicts. Early detection of nephropathy with biochemical indicators might help prevent severe conditions that require hospitalization and intensive care.
- Subjects :
- Adult
Biomarkers urine
CD4-Positive T-Lymphocytes
Comorbidity
Female
HIV Infections epidemiology
HIV Infections urine
Healthy Volunteers
Hepatitis C epidemiology
Hepatitis C urine
Humans
Isoenzymes urine
Lipocalin-2
Male
Middle Aged
Substance-Related Disorders epidemiology
Viral Load
Young Adult
Acute-Phase Proteins urine
Interleukin-18 urine
Kidney Function Tests methods
Lipocalins urine
Proto-Oncogene Proteins urine
Substance-Related Disorders diagnosis
Substance-Related Disorders urine
beta 2-Microglobulin urine
Subjects
Details
- Language :
- English
- ISSN :
- 1732-2693
- Volume :
- 67
- Database :
- MEDLINE
- Journal :
- Postepy higieny i medycyny doswiadczalnej (Online)
- Publication Type :
- Academic Journal
- Accession number :
- 24379262
- Full Text :
- https://doi.org/10.5604/17322693.1078854