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Asymmetric reduction of diynones and the total synthesis of (S)-panaxjapyne A.
- Source :
-
Organic letters [Org Lett] 2014 Jan 17; Vol. 16 (2), pp. 374-7. Date of Electronic Publication: 2013 Dec 30. - Publication Year :
- 2014
-
Abstract
- The asymmetric transfer hydrogenation of a series of diynones has been achieved in high conversion and enantiomeric induction. When R(1) is a phenyl group, a competing alkyne reduction takes place; however, when R(1) is an alkyl group, this side-reaction is not observed. The application of the reduction to the total synthesis of the natural product (S)-panaxjapyne A in high enantiomeric excess is described.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 24377788
- Full Text :
- https://doi.org/10.1021/ol4032123