Highly N2-selective coupling of 1,2,3-triazoles with indole and pyrrole.

Authors :: Wen J
Zhu LL
Bi QW
Shen ZQ
Li XX
Li X
Wang Z
Chen Z
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2014 Jan 20; Vol. 20 (4), pp. 974-8. Date of Electronic Publication: 2013 Dec 16.
Publication Year :: 2014
Abstract: Hydrogen-bond mediated coupling of 1,2,3-triazoles to indoles and pyrroles results in N2 selective functionalization of the triazole moiety in moderate to excellent yields. The reaction was tolerant of un-, mono- and disubstituted triazoles and was applied to synthesize tryptophan derived fluorescent amino acids.<br /> (Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)