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Whole-body CT angiography with low tube voltage and low-concentration contrast material to reduce radiation dose and iodine load.
- Source :
-
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2014 Jan; Vol. 202 (1), pp. W106-16. - Publication Year :
- 2014
-
Abstract
- Objective: The purpose of this study was to prospectively evaluate the contrast enhancement, vascular depiction, image quality, and radiation dose of low-tube-voltage whole-body CT angiography (CTA) performed with low-concentration iodinated contrast material.<br />Subjects and Methods: Whole-body CTA was performed on 109 patients with a 64-MDCT scanner. Patients were randomized into three groups: CTA with 240-mg/mL contrast material at 80 kVp (240-80 group), 300-mg/mL at 80 kVp (300-80 group), and 370-mg/mL at 120 kVp (370-120 group). Signal-to-noise ratio (SNR), arterial depiction, image quality, and radiation dose were assessed. Figure of merit was computed to normalize signal-to-noise ratio, estimated effective dose, and iodine weight.<br />Results: In the 240-80 group, the mean load of administered iodine was 21.6 g; for the 300-80 group, 26.8 g; and the 370-120 group, 34.0 g (p < 0.05). The ranges of mean vascular enhancement were 508-521 HU, 546-593 HU, and 435-442 HU (p < 0.05). Arterial depiction and image quality were comparable for the 240-80 and 370-120 groups and were greater for the 300-80 group than the other two groups in selected arteries (p < 0.05). Effective dose was higher (p < 0.05) in the 370-120 group (2.8-5.4 mSv) than in the others (2.3-4.3 mSv). The figure of merit in the 240-80 group was greater than (p < 0.05) or comparable to that in the 370-120 group.<br />Conclusion: Use of 240-mg/mL contrast material at 80 kVp seems appropriate for routine whole-body CTA and beneficial for reduction of iodine load and radiation dose, whereas use of 300-mg/mL contrast material may marginally improve delineation of selected small arteries.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Iohexol administration & dosage
Iopamidol administration & dosage
Male
Middle Aged
Prospective Studies
Signal-To-Noise Ratio
Triiodobenzoic Acids administration & dosage
Whole Body Imaging
Angiography methods
Contrast Media administration & dosage
Radiation Dosage
Tomography, X-Ray Computed methods
Vascular Diseases diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1546-3141
- Volume :
- 202
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- AJR. American journal of roentgenology
- Publication Type :
- Academic Journal
- Accession number :
- 24370154
- Full Text :
- https://doi.org/10.2214/AJR.13.10720