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Helicobacter pylori and interleukin-8 in gastric cancer.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2013 Dec 07; Vol. 19 (45), pp. 8192-202. - Publication Year :
- 2013
-
Abstract
- Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer.<br /> (© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Cell Transformation, Neoplastic chemically induced
Cell Transformation, Neoplastic immunology
Cell Transformation, Neoplastic metabolism
Drug Design
Gastric Mucosa immunology
Helicobacter Infections epidemiology
Helicobacter Infections immunology
Helicobacter pylori immunology
Humans
Interleukin-8 antagonists & inhibitors
Molecular Targeted Therapy
Prognosis
Receptors, Interleukin-8 antagonists & inhibitors
Receptors, Interleukin-8 metabolism
Risk Factors
Signal Transduction
Stomach Neoplasms immunology
Gastric Mucosa metabolism
Gastric Mucosa microbiology
Helicobacter Infections metabolism
Helicobacter Infections microbiology
Helicobacter pylori pathogenicity
Interleukin-8 metabolism
Stomach Neoplasms metabolism
Stomach Neoplasms microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 19
- Issue :
- 45
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 24363509
- Full Text :
- https://doi.org/10.3748/wjg.v19.i45.8192