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Metabotropic glutamatergic receptors and their ligands in drug addiction.
- Source :
-
Pharmacology & therapeutics [Pharmacol Ther] 2014 Jun; Vol. 142 (3), pp. 281-305. Date of Electronic Publication: 2013 Dec 19. - Publication Year :
- 2014
-
Abstract
- Glutamatergic excitatory transmission is implicated in physiological and pathological conditions like learning, memory, neuronal plasticity and emotions, while glutamatergic abnormalities are reported in numerous neurological and psychiatric disorders, including neurodegenerative diseases, epilepsy, stroke, traumatic brain injury, depression, anxiety, schizophrenia and pain. Also, several lines of evidence have accumulated indicating a pivotal role for glutamatergic neurotransmission in mediating addictive behaviors. Among the proteins regulating glutamatergic transmission, the metabotropic glutamate receptors (mGluR) are being developed as pharmacological targets for treating many neuropsychiatric disorders, including drug addiction. In this review we describe the molecular structure of mGluRs and their distribution, physiology and pharmacology in the central nervous system, as well as their use as targets in preclinical studies of drug addiction.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Glutamic Acid metabolism
Humans
Ligands
Receptors, Metabotropic Glutamate analysis
Receptors, Metabotropic Glutamate drug effects
Receptors, Metabotropic Glutamate genetics
Substance-Related Disorders drug therapy
Receptors, Metabotropic Glutamate physiology
Substance-Related Disorders etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-016X
- Volume :
- 142
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 24362085
- Full Text :
- https://doi.org/10.1016/j.pharmthera.2013.12.012