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Behavioral and biochemical changes following acute administration of MPTP and MPP+.
- Source :
-
Life sciences [Life Sci] 1987 Mar 30; Vol. 40 (13), pp. 1309-18. - Publication Year :
- 1987
-
Abstract
- The acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ion (MPP+) on mouse locomotor activity and striatal dopamine (DA) and 5-hydroxytryptamine (5-HT) levels were investigated. A single dose of either MPTP (10-30 mg/kg, i.p.) or MPP+ (5-20 ug/mouse, i.c.v.) decreased locomotor activity 10-40 min after injection: this locomotor effect was significantly suppressed by either pretreatment with nomifensine or 1-deprenyl alone, or by the combination of desmethylimipramine and 6-hydroxydopamine. Pretreatment with clorgyline did not suppress this behavior and a single dose of haloperidol enhanced the effect. The striatal levels of DA, 3-methoxytyramine and 5-HT increased in parallel with the decrease in locomotor activity caused by MPTP or MPP+. In contrast, levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid were decreased by injection of either MPTP or MPP+. Possible mechanism(s) of the behavioral and biochemical changes caused by the acute actions of MPTP and MPP+ with respect to their neurotoxic effects on the nigrostriatal DA system are discussed.
- Subjects :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenylpyridinium
3,4-Dihydroxyphenylacetic Acid analysis
Animals
Corpus Striatum analysis
Desipramine pharmacology
Dopamine analogs & derivatives
Homovanillic Acid analysis
Hydroxyindoleacetic Acid analysis
Male
Mice
Nomifensine pharmacology
Selegiline pharmacology
Corpus Striatum drug effects
Dopamine analysis
Motor Activity drug effects
Pyridines pharmacology
Pyridinium Compounds pharmacology
Serotonin analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 40
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 2436017
- Full Text :
- https://doi.org/10.1016/0024-3205(87)90588-1