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Diagnostic dilemma of unicystic ameloblastoma: novel parameters to differentiate unicystic ameloblastoma from common odontogenic cysts.
- Source :
-
Journal of investigative and clinical dentistry [J Investig Clin Dent] 2014 Aug; Vol. 5 (3), pp. 220-5. Date of Electronic Publication: 2013 Dec 20. - Publication Year :
- 2014
-
Abstract
- Aim: Diagnostic criteria that have been specified for unicystic ameloblastomas (UAs) are not always helpful to differentiate these cystic tumors from common odontogenic cysts. The aim of this study therefore was to identify additional histopathological features (other than the features considered for the diagnosis of UA at present) that would be helpful to differentiate UA from odontogenic cysts.<br />Methods: One hundred histopathologically confirmed unicystic ameloblastomas and 20 cases each of radicular, inflamed dentigerous and non-inflamed dentigerous cysts were selected. Histopathological features of the UAs that are not used as diagnostic criteria at present were identified.<br />Results: Hyperplastic arcading epithelial proliferations with stellate-reticulum-like and vacuolated cells were always seen associated with inflammation in odontogenic cysts, while in UA plexiform-like areas were also seen without inflammation (P < 0.001). In addition, a spiky rete pattern was observed in non-inflamed UA while this pattern was observed only in inflamed odontogenic cysts. Furthermore, spiky retes together with subepithelial hyalinization were usually observed in UAs while only subepithelial hyalinization was observed in non-inflamed dentigerous cysts.<br />Conclusions: Combinations of histopathological features were identified to differentiate non-inflamed UA from common odontogenic cysts. However, presence of inflammatory changes in UA precludes the use of features identified in the present study for diagnostic purposes.<br /> (© 2013 Wiley Publishing Asia Pty Ltd.)
- Subjects :
- Ameloblastoma pathology
Ameloblasts pathology
Connective Tissue pathology
Dentigerous Cyst pathology
Diagnosis, Differential
Epithelial Cells pathology
Epithelium pathology
Female
Humans
Hyalin chemistry
Hyperplasia
Inflammation pathology
Keratins analysis
Male
Radicular Cyst pathology
Vacuoles ultrastructure
Young Adult
Ameloblastoma diagnosis
Dentigerous Cyst diagnosis
Radicular Cyst diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1626
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of investigative and clinical dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 24357580
- Full Text :
- https://doi.org/10.1111/jicd.12071