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Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2014 Feb; Vol. 35 (2), pp. 1351-6. Date of Electronic Publication: 2013 Dec 20. - Publication Year :
- 2014
-
Abstract
- Matrix metalloproteinases (MMPs) play an important role in breast cancer tumor invasion and progression. MMP-9 is a member of the MMP family and is also known as Gelatinase B or type IV collagenases (92 kDa) and possesses proteolytic activity against type IV collagen, a major component of the basement membrane. Our study aims to examine the association of Gelatinase B (-1562C > T) promoter polymorphism with breast cancer invasion and progression. The study involves 200 breast cancer patients and age-matched 191 healthy controls. The SNP-1562C > T (rs3918242) in MMP-9 promoter region was examined by allele-specific polymerase chain reaction and gel electrophoresis. The genotypes were determined and compared between patients and controls, and the influence of the polymorphism on clinicopathological data was analyzed. The T allele of the -1562C > T MMP-9 polymorphism was detected more frequently in breast cancer patients than controls (p < 0.001). Our results suggest the clinical importance of MMP-9 gene polymorphism (-1562C > T) in breast cancer patients. The study may also help in identifying individuals at risk of developing breast cancer.
- Subjects :
- Adult
Aged
Breast Neoplasms enzymology
Breast Neoplasms pathology
Female
Gene Expression Regulation, Neoplastic
Genetic Association Studies
Humans
Middle Aged
Neoplasm Staging
Polymorphism, Genetic
Prognosis
Promoter Regions, Genetic
Breast Neoplasms genetics
Disease Progression
Matrix Metalloproteinase 9 genetics
Neoplasm Invasiveness genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 35
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24357512
- Full Text :
- https://doi.org/10.1007/s13277-013-1181-5