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Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts.
- Source :
-
Biogerontology [Biogerontology] 2014 Apr; Vol. 15 (2), pp. 165-76. Date of Electronic Publication: 2013 Dec 18. - Publication Year :
- 2014
-
Abstract
- Senescence phenotype can be achieved by multiple pathways. Most of them involve the activation of negative cell cycle regulators as well as a shift to an oxidative status. However, the exact participation of these events in senescence establishment and maintenance is not completely understood. In this study we investigated the content of three final cell cycle regulators, as well as the redox state in some critical points during the pre-senescent and the full-senescent states. Our results highlight the existence of a critical pre-phase in senescent phenotype establishment, in which cell proliferation stops with the participation of the cell cycle inhibitors, and a second maintenance stage where the exacerbated pro-oxidant state inside the cell induces the physiological decline characteristic in senescent cells.
- Subjects :
- Animals
Antioxidants pharmacology
Cell Cycle Checkpoints physiology
Cell Proliferation
Cells, Cultured
Cellular Senescence drug effects
Chromans pharmacology
DNA biosynthesis
Fibroblasts drug effects
Glutathione metabolism
Glutathione Disulfide metabolism
Mice
Oxidation-Reduction
Phenotype
Protein Carbonylation
Cellular Senescence physiology
Fibroblasts cytology
Fibroblasts metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6768
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biogerontology
- Publication Type :
- Academic Journal
- Accession number :
- 24347027
- Full Text :
- https://doi.org/10.1007/s10522-013-9488-6