Synthesis and biological evaluation of paleo-soraphens.

Authors :: Lu HH
Raja A
Franke R
Landsberg D
Sasse F
Kalesse M
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 Dec 16; Vol. 52 (51), pp. 13549-52. Date of Electronic Publication: 2013 Nov 07.
Publication Year :: 2013
Abstract: Synthesis can provide molecules such as paleo-soraphens A and B that are genetically encoded but not obtained from the natural source. Although it is unclear whether this is part of an evolutionary process or the consequence of the chemical synthesis, the biological evaluation of these genetically encoded natural products can shed light on how natural products are structurally optimized with respect to their biological profile.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)