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Prostaglandin D(2) is crucial for seizure suppression and postictal sleep.
- Source :
-
Experimental neurology [Exp Neurol] 2014 Mar; Vol. 253, pp. 82-90. Date of Electronic Publication: 2013 Dec 10. - Publication Year :
- 2014
-
Abstract
- Epilepsy is a neurological disorder with the occurrence of seizures, which are often accompanied by sleep. Prostaglandin (PG) D2 is produced by hematopoietic or lipocalin-type PGD synthase (H- or L-PGDS) and involved in the regulation of physiological sleep. Here, we show that H-PGDS, L/H-PGDS or DP1 receptor (DP1R) KO mice exhibited more intense pentylenetetrazole (PTZ)-induced seizures in terms of latency of seizure onset, duration of generalized tonic-clonic seizures, and number of seizure spikes. Seizures significantly increased the PGD2 content of the brain in wild-type mice. This PTZ-induced increase in PGD2 was attenuated in the brains of L- or H-PGDS KO and abolished in L/H-PGDS KO mice. Postictal non-rapid eye movement sleep was observed in the wild-type and H-PGDS or DP2R KO, but not in the L-, L/H-PGDS or DP1R KO, mice. These findings demonstrate that PGD2 produced by H-PGDS and acting on DP1R is essential for seizure suppression and that the L-PGDS/PGD2/DP1R system regulates sleep that follows seizures.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- 6-Ketoprostaglandin F1 alpha metabolism
Analysis of Variance
Animals
Brain drug effects
Brain metabolism
Convulsants toxicity
Dinoprostone metabolism
Disease Models, Animal
Electroencephalography
Electromyography
Intramolecular Oxidoreductases deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
Pentylenetetrazole toxicity
Receptors, Thromboxane A2, Prostaglandin H2 metabolism
Seizures chemically induced
Seizures genetics
Sleep, REM drug effects
Sleep, REM genetics
Time Factors
Transcription Factor DP1 deficiency
Intramolecular Oxidoreductases physiology
Lipocalins physiology
Seizures metabolism
Seizures physiopathology
Sleep, REM physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2430
- Volume :
- 253
- Database :
- MEDLINE
- Journal :
- Experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 24333565
- Full Text :
- https://doi.org/10.1016/j.expneurol.2013.12.002