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Renal and pulmonary late effects of cancer therapy.
- Source :
-
Seminars in oncology [Semin Oncol] 2013 Dec; Vol. 40 (6), pp. 757-73. - Publication Year :
- 2013
-
Abstract
- Both the kidneys and lungs are susceptible to the toxic effects of cancer therapy, with specific chemotherapy agents, as well as radiation therapy, leading to acute toxicities and the risk for long-term dysfunction. The kidneys also are vulnerable to the direct impact of the cancer itself and to supportive care drugs such as certain anti-infectives and immunosuppressive agents, nonsteroidal anti-inflammatories, and radiocontrast media. The lungs are especially vulnerable after hematopoietic stem cell transplantation (HSCT), particularly in patients who develop chronic graft-versus-host disease. This article will discuss the epidemiology, specific risk factors, pathogenesis, natural history, recommended screening, preventive strategies, treatment, and areas for future research into renal and pulmonary toxicity in survivors of cancer.<br /> (© 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Contrast Media adverse effects
Graft vs Host Disease etiology
Hematopoietic Stem Cell Transplantation adverse effects
Humans
Hypertension, Pulmonary etiology
Hypertension, Pulmonary therapy
Lung Diseases therapy
Lung Diseases, Interstitial etiology
Lung Diseases, Interstitial therapy
Lung Injury etiology
Lung Injury therapy
Radiation Injuries therapy
Renal Insufficiency, Chronic prevention & control
Renal Insufficiency, Chronic therapy
Antineoplastic Agents adverse effects
Lung Diseases etiology
Neoplasms therapy
Radiotherapy adverse effects
Renal Insufficiency, Chronic etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8708
- Volume :
- 40
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Seminars in oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24331195
- Full Text :
- https://doi.org/10.1053/j.seminoncol.2013.09.009