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CAR T cells: driving the road from the laboratory to the clinic.
- Source :
-
Immunological reviews [Immunol Rev] 2014 Jan; Vol. 257 (1), pp. 91-106. - Publication Year :
- 2014
-
Abstract
- Blockbuster antibody therapies have catapulted immune-based approaches to treat cancer into the consciousness of mainstay clinical research. On the back of this, other emerging immune-based therapies are providing great promise. T-cell therapy is one such area where recent trials using T cells genetically modified to express an antibody-based chimeric antigen receptor (CAR) targeted against the CD19 antigen have demonstrated impressive responses when adoptively transferred to patients with advanced chronic lymphocytic leukemia. The general concept of the CAR T cell was devised some 20 years ago. In this relatively short period of time, the technology to redirect T-cell function has moved at pace facilitating clinical translation; however, many questions remain with respect to developing the approach to improve CAR T-cell therapeutic activity and also to broaden the range of tumors that can be effectively targeted by this approach. This review highlights some of the underlying principles and compromises of CAR T-cell technology using the CD19-targeted CAR as a paradigm and discusses some of the issues that relate to targeting solid tumors with CAR T cells.<br /> (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Animals
Cancer Vaccines genetics
Cancer Vaccines immunology
Cell Culture Techniques
Gene Transfer Techniques
Genetic Engineering
Humans
Immunotherapy, Adoptive adverse effects
Immunotherapy, Adoptive methods
Leukemia, B-Cell immunology
Leukemia, B-Cell therapy
Lymphoma, B-Cell immunology
Lymphoma, B-Cell therapy
Antigens, CD19 immunology
Receptors, Antigen, T-Cell genetics
Receptors, Antigen, T-Cell metabolism
T-Lymphocyte Subsets immunology
T-Lymphocyte Subsets metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1600-065X
- Volume :
- 257
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunological reviews
- Publication Type :
- Academic Journal
- Accession number :
- 24329792
- Full Text :
- https://doi.org/10.1111/imr.12126