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Cutaneous melanoma in patients treated with tumour necrosis factor inhibitors: a retrospective series of 15 patients.
- Source :
-
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2014 Nov; Vol. 28 (11), pp. 1540-4. Date of Electronic Publication: 2013 Dec 13. - Publication Year :
- 2014
-
Abstract
- Background: Several case reports suggested that tumour necrosis factor-α (TNF) inhibitors might increase the incidence and/or alter the natural course of melanoma towards a more aggressive behaviour.<br />Objective: Our objective was to point if history of melanoma in patients exposed to TNF inhibitors could present with a particular pattern at diagnosis or during follow-up.<br />Methods: We performed a retrospective multicentre study settled in the West part of France to collect and analyse all cases of patients with melanoma who received anti-TNF therapy.<br />Results: Fifteen cases were included. First, 10 patients (mean age: 55.6 years; sex ratio: 1) had a melanoma diagnosed after TNF inhibitors initiation. The mean duration between initiation of treatment and melanoma was 48.7 months. Two patients died of metastatic disease. Second, four patients had a past history of melanoma before anti-TNF therapy (mean duration of treatment: 10.8 months). None experienced a progression of melanoma disease. Last, one woman had a past history of melanoma before and then developed a second melanoma when exposed to biotherapy.<br />Conclusion: Our case series does not reveal a distinct profile of melanoma in the patients exposed to TNF inhibitors. Additional prospective trials including larger number of patient are needed to demonstrate the possible link between biological therapy with TNF inhibitors and development of melanoma.<br /> (© 2013 European Academy of Dermatology and Venereology.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antirheumatic Agents adverse effects
Antirheumatic Agents therapeutic use
Female
Follow-Up Studies
France
Humans
Incidence
Male
Middle Aged
Neoplasm Recurrence, Local epidemiology
Retrospective Studies
Risk Factors
Biological Products adverse effects
Biological Products therapeutic use
Melanoma epidemiology
Rheumatic Diseases drug therapy
Skin Neoplasms epidemiology
Tumor Necrosis Factor-alpha antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1468-3083
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of the European Academy of Dermatology and Venereology : JEADV
- Publication Type :
- Academic Journal
- Accession number :
- 24329560
- Full Text :
- https://doi.org/10.1111/jdv.12347