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Predictive value of casual ECG-based resting heart rate compared with resting heart rate obtained from Holter recording.
- Source :
-
Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2014 Mar; Vol. 74 (2), pp. 163-9. Date of Electronic Publication: 2013 Dec 13. - Publication Year :
- 2014
-
Abstract
- Background: Elevated resting heart rate (RHR) is associated with cardiovascular mortality and morbidity. Assessment of heart rate (HR) from Holter recording may afford a more precise estimate of the effect of RHR on cardiovascular risk, as compared to casual RHR. Comparative analysis was carried out in an age-stratified subsample of 131 subjects in the Copenhagen City Heart Study (CCHS).<br />Methods: Casual RHR was assessed from electrocardiograms recorded during clinical assessment. Hourly daytime HRs were mapped by Holter recording. Holter RHR was defined as the average of the lowest 3 hourly HRs recorded and mean HR calculated from all daytime HRs. Follow-up was recorded from public registers. Outcome measure was hazard rate for the combined endpoint of cardiovascular mortality, non-fatal heart failure and non-fatal acute myocardial infarction. Comparison of casual RHR, Holter RHR and mean HR by Multivariate Cox regression was performed.<br />Results: A total of 57 composite endpoints occurred during 17.1 years of follow-up. Regression analysis suggests correlation between Casual RHR and Holter RHR. Multivariate Cox regression analysis adjusted for gender and age demonstrated hazard rates of 1.02 (p = 0.079) for casual RHR, 1.04 (p = 0.036*) for Holter RHR, and 1.03 (p = 0.093) for mean HR for each 10 beat increment in HR.<br />Conclusions: In a comparative analysis on the correlation and significance of differing RHR measurement modalities RHR measured by 24-hour Holter recording was found to be marginally superior as a predictor of cardiovascular morbidity and mortality. The results presented here do not however warrant the abandonment of a tested epidemiological variable.
- Subjects :
- Adult
Aged
Female
Heart Failure mortality
Heart Failure physiopathology
Humans
Male
Middle Aged
Myocardial Infarction mortality
Myocardial Infarction physiopathology
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
Rest
Risk Factors
Survival Analysis
Electrocardiography methods
Heart Failure diagnosis
Heart Rate
Myocardial Infarction diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1502-7686
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of clinical and laboratory investigation
- Publication Type :
- Academic Journal
- Accession number :
- 24329133
- Full Text :
- https://doi.org/10.3109/00365513.2013.867531