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Radical route for the alkylation of purine nucleosides at C6 via Minisci reaction.
- Source :
-
Organic letters [Org Lett] 2014 Jan 17; Vol. 16 (2), pp. 444-7. Date of Electronic Publication: 2013 Dec 16. - Publication Year :
- 2014
-
Abstract
- A highly regioselective Minisci reaction with the decarboxylative alkylation of purine nucleosides under mild conditions was developed. With 5 mol % AgNO3 as a catalyst and (NH4)2S2O8 as an oxidant, a series of purine nucleosides including ribosyl, deoxyribosyl, arabinosyl purine nucleosides worked well with primary, secondary, and tertiary aliphatic carboxylic acids.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 24328916
- Full Text :
- https://doi.org/10.1021/ol4033336