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Early IFN-gamma production after YF 17D vaccine virus immunization in mice and its association with adaptive immune responses.
- Source :
-
PloS one [PLoS One] 2013 Dec 06; Vol. 8 (12), pp. e81953. Date of Electronic Publication: 2013 Dec 06 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- Yellow Fever vaccine is one of the most efficacious human vaccines ever made. The vaccine (YF 17D) virus induces polyvalent immune responses, with a mixed TH1/TH2 CD4(+) cell profile, which results in robust T CD8(+) responses and high titers of neutralizing antibody. In recent years, it has been suggested that early events after yellow fever vaccination are crucial to the development of adequate acquired immunity. We have previously shown that primary immunization of humans and monkeys with YF 17D virus vaccine resulted in the early synthesis of IFN-γ. Herein we have demonstrated, for the first time that early IFN-γ production after yellow fever vaccination is a feature also of murine infection and is much more pronounced in the C57BL/6 strain compared to the BALB/c strain. Likewise, in C57BL/6 strain, we have observed the highest CD8(+) T cells responses as well as higher titers of neutralizing antibodies and total anti-YF IgG. Regardless of this intense IFN-γ response in mice, it was not possible to see higher titers of IgG2a in relation to IgG1 in both mice lineages. However, IgG2a titers were positively correlated to neutralizing antibodies levels, pointing to an important role of IFN-γ in eliciting high quality responses against YF 17D, therefore influencing the immunogenicity of this vaccine.
- Subjects :
- Animals
Antibodies, Neutralizing immunology
Antibody Formation immunology
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Chlorocebus aethiops
Female
Gene Products, gag immunology
Humans
Immunoglobulin G blood
Killer Cells, Natural immunology
Lymph Nodes immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Receptors, Antigen, T-Cell, gamma-delta metabolism
Recombination, Genetic genetics
Spleen immunology
Vero Cells
Yellow Fever blood
Yellow Fever virology
Adaptive Immunity immunology
Immunization
Interferon-gamma biosynthesis
Yellow Fever immunology
Yellow Fever prevention & control
Yellow Fever Vaccine immunology
Yellow fever virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24324734
- Full Text :
- https://doi.org/10.1371/journal.pone.0081953