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Predictors of bacteremia among children with sickle cell disease presenting with fever.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2014 Jul; Vol. 36 (5), pp. 384-8. - Publication Year :
- 2014
-
Abstract
- Introduction: Bacterial sepsis is more common and potentially life threatening in children with sickle cell disease (SCD). Identification of variables that predict bacteremia may aid clinicians in recognizing patients with SCD at higher risk for sepsis.<br />Objective: To determine whether absolute neutrophil count (ANC) >20×10/L is an independent risk factor for bacteremia in children with SCD and to identify other predictors of bacteremia in this population.<br />Methods: A case-control study was conducted. Subjects were 0 to 18 years of age admitted to a tertiary care pediatric hospital over a 17-year period with SCD and fever at presentation. Cases had bacteremia, whereas controls had negative blood cultures.<br />Results: Data were analyzed for 40 cases and 120 controls. ANC>20×10/L was significantly more prevalent among cases (odds ratio [OR], 7.0; 95% confidence interval [CI], 2.6-18.9). Cases were more likely to have emesis (OR, 2.9; 95% CI, 1.0-8.4) and a higher proportion of band cells (OR, 1.3; 95% CI, 1.1-1.4) at presentation.<br />Conclusions: In a febrile child with SCD, an ANC>20×10/L, a higher proportion of band cells, and the presence of vomiting were associated with an increased likelihood of bacteremia.
- Subjects :
- Adolescent
Anemia, Sickle Cell complications
Anemia, Sickle Cell therapy
Bacteremia blood
Bacteremia etiology
Case-Control Studies
Child
Child, Preschool
Female
Fever blood
Fever etiology
Follow-Up Studies
Humans
Infant
Infant, Newborn
Leukocyte Count
Male
Prognosis
Risk Factors
Vomiting blood
Vomiting etiology
Anemia, Sickle Cell microbiology
Bacteremia diagnosis
Fever diagnosis
Vomiting diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24309605
- Full Text :
- https://doi.org/10.1097/MPH.0000000000000070