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Changes in vitamin D and matrix metalloproteinase-9 in submariners during a submerged patrol.
- Source :
-
Occupational and environmental medicine [Occup Environ Med] 2014 Feb; Vol. 71 (2), pp. 104-8. Date of Electronic Publication: 2013 Dec 04. - Publication Year :
- 2014
-
Abstract
- Objectives: To quantify changes in vitamin D and matrix metalloproteinase-9 (MMP9) in submariners over a single long patrol and compare the data to a group of non-deploying servicemen from their base port.<br />Methods: A prospective time-series analysis was performed. Blood samples were taken from 49 submariners deploying on patrol and 43 shore-side controls from the base port (naval officers from base or non-deploying submariners), following a winter ashore at latitude 56° north. Samples were drawn immediately before the submarine sailed, in January, and again in the final week of patrol 85 days later. Paired pre-patrol and late samples from each individual were assayed together and changes in vitamin D and MMP9 were assessed.<br />Results: Mean pre-patrol vitamin D concentrations were 58 and 49 nmol/L for the controls and submariners, respectively. Mean vitamin D concentrations increased in controls as expected (mean increase 12.6 nmol/L), but not in the submariners (mean decrease 1.6 nmol/L). MMP9 levels were significantly higher in submariners pre-patrol, and increased significantly during the patrol. There was a significant inverse correlation between MMP9 and vitamin D levels (r=-0.41, p=0.01).<br />Conclusions: This is the first study to quantify vitamin D and MMP levels in submariners. Circulating vitamin D concentrations on board were insufficient to prevent a rise in MMP. This has potential for adverse health effects and requires further study.
Details
- Language :
- English
- ISSN :
- 1470-7926
- Volume :
- 71
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Occupational and environmental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24306365
- Full Text :
- https://doi.org/10.1136/oemed-2013-101793