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Poly-combing the genome for RNA.

Authors :
Goff LA
Rinn JL
Source :
Nature structural & molecular biology [Nat Struct Mol Biol] 2013 Dec; Vol. 20 (12), pp. 1344-6.
Publication Year :
2013

Abstract

An unresolved question in mammalian epigenetic regulation is how ubiquitously expressed chromatin-modifying complexes such as Polycomb group complex 2 (PRC2) find their specific target sites across an intricate choreography of localization events in time and space. Two recent studies now provide critical new insights into an intriguing genome-wide role for RNA in PRC2 regulation.

Details

Language :
English
ISSN :
1545-9985
Volume :
20
Issue :
12
Database :
MEDLINE
Journal :
Nature structural & molecular biology
Publication Type :
Periodical
Accession number :
24304912
Full Text :
https://doi.org/10.1038/nsmb.2728