Back to Search
Start Over
Plasma levels of soluble tumor necrosis factor receptors are associated with cognitive performance in Parkinson's disease.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2014 Apr; Vol. 29 (4), pp. 527-31. Date of Electronic Publication: 2013 Dec 03. - Publication Year :
- 2014
-
Abstract
- Inflammatory mechanisms have been implicated in a series of neuropsychiatric conditions, including behavioral disturbances, cognitive dysfunction, and affective disorders. Accumulating evidence also strongly suggests their involvement in the pathophysiology of Parkinson's disease (PD). This study aimed to evaluate plasma levels of inflammatory biomarkers, and their association with cognitive performance and other non-motor symptoms of PD. PD patients and control individuals were subjected to various psychometric tests, including the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck's Depression Inventory (BDI). Biomarker plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). PD patients exhibited worse performance on MMSE and the programming task of FAB, and presented higher soluble tumor necrosis factor receptor (sTNFR) plasma levels than control individuals. Among PD patients, increased sTNFR1 and sTNFR2 concentrations were associated with poorer cognitive test scores. After multiple linear regression, sTNFR1 and education remained a significant predictor for FAB scores. Our data suggest that PD is associated with a proinflammatory profile, and sTNFRs are putative biomarkers of cognitive performance, with elevated sTNFR1 levels predicting poorer executive functioning in PD patients.<br /> (© 2013 International Parkinson and Movement Disorder Society.)
- Subjects :
- Aged
Biomarkers blood
Cognition Disorders blood
Cognition Disorders complications
Executive Function physiology
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Parkinson Disease complications
Cognition physiology
Cognition Disorders diagnosis
Parkinson Disease blood
Parkinson Disease psychology
Receptors, Tumor Necrosis Factor blood
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 24301904
- Full Text :
- https://doi.org/10.1002/mds.25752