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Src regulates membrane trafficking of the Kv3.1b channel.
- Source :
-
FEBS letters [FEBS Lett] 2014 Jan 03; Vol. 588 (1), pp. 86-91. Date of Electronic Publication: 2013 Nov 26. - Publication Year :
- 2014
-
Abstract
- The Kv3.1 channel plays a crucial role in regulating the high-frequency firing properties of neurons. Here, we determined whether Src regulates the subcellular distributions of the Kv3.1b channel. Co-expression of active Src induced a dramatic redistribution of Kv3.1b to the endoplasmic reticulum. Furthermore, co-expression of the Kv3.1b channel with active Src induced a remarkable decrease in the pool of Kv3.1b at the cell surface. Moreover, the co-expression of active Src results in a significant decrease in the peak current densities of the Kv3.1b channel, and a substantial alteration in the voltage dependence of its steady-state inactivation. Taken together, these results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels.<br /> (Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Blotting, Western
COS Cells
Cell Membrane physiology
Chlorocebus aethiops
HEK293 Cells
Humans
Membrane Potentials physiology
Mice
Mutagenesis, Site-Directed
Nerve Tissue Proteins genetics
Nerve Tissue Proteins physiology
Patch-Clamp Techniques
Protein Transport
Proto-Oncogene Proteins pp60(c-src) genetics
Rats
Shaw Potassium Channels genetics
Shaw Potassium Channels physiology
Cell Membrane metabolism
Endoplasmic Reticulum metabolism
Nerve Tissue Proteins metabolism
Proto-Oncogene Proteins pp60(c-src) metabolism
Shaw Potassium Channels metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 588
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 24291260
- Full Text :
- https://doi.org/10.1016/j.febslet.2013.11.010