Diaminocyclopropenylidene organocatalysts: beyond N-heterocyclic carbenes.

Authors :: Connon SJ
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Jan 27; Vol. 53 (5), pp. 1203-5. Date of Electronic Publication: 2013 Nov 28.
Publication Year :: 2014
Abstract: Cyclopropenylidene carbenes have been found to be efficient catalysts for the intermolecular Stetter reaction between aromatic aldehydes and α,β-unsaturated ketones. In this transformation, the cyclopropenylidene proved superior to more traditional thiazolium- and triazolium-derived carbenes. Preparation and evaluation of a chiral analogue have also been reported.<br /> (Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)