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Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study.
- Source :
-
Endocrine [Endocrine] 2014 Aug; Vol. 46 (3), pp. 585-93. Date of Electronic Publication: 2013 Nov 27. - Publication Year :
- 2014
-
Abstract
- Pituitary adenomas (PAs) represent 15 % of all brain tumors. One-sixth of these are reported to cause acromegaly via excess growth hormone secretion. These tumors have been associated with multiple comorbidities, including neuropsychiatric and cognitive dysfunction. We aimed to assess patient perception of cognitive deficits and the relationship of cognitive changes to active acromegaly (AA) versus controlled acromegaly (CA) versus non-functional PAs (NFPA). A modified FACT-Cog survey was used, which focused on the prevalence and severity of perceived dysfunction in five areas of cognitive function: ability to learn, concentration/distractibility, mental agility, memory and recall, and verbal recall. Patient perception of current health and health change over the previous 12 months was also assessed. The overall perceived prevalence and severity of cognitive dysfunction were the highest among NFPA groups, particularly in the areas of mental agility, verbal recall, and memory/recall. Patients with AA reported greater prevalence and severity of dysfunction with respect to concentration/distractibility and ability to learn. Patients with AA reported the best overall current health, though patients with CA reported the greatest improvement in health over the previous year. These findings may indicate that PAs can affect cognitive function regardless of whether excess growth hormone is present. Acromegaly and NFPA patients perceive specific areas of cognitive dysfunction that may require further evaluation and treatment. Further research may be useful regarding patient quality of life, patient functionality during normal daily activities, and perceived dysfunction despite biological disease control.
- Subjects :
- Acromegaly complications
Adenoma complications
Cognition Disorders complications
Cognition Disorders psychology
Female
Health Status
Humans
Male
Memory
Middle Aged
Pilot Projects
Pituitary Neoplasms complications
Prospective Studies
Quality of Life
Surveys and Questionnaires
Acromegaly psychology
Adenoma psychology
Cognition
Cognition Disorders diagnosis
Pituitary Neoplasms psychology
Self Concept
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0100
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Endocrine
- Publication Type :
- Academic Journal
- Accession number :
- 24282035
- Full Text :
- https://doi.org/10.1007/s12020-013-0106-9