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Curcumin glucuronides: assessing the proliferative activity against human cell lines.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Jan 01; Vol. 22 (1), pp. 435-9. Date of Electronic Publication: 2013 Nov 12. - Publication Year :
- 2014
-
Abstract
- A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat cell, U266, and A549 cell lines were reported. Biological data revealed that as much as 1 μM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 μM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.<br /> (Copyright © 2013. Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24280069
- Full Text :
- https://doi.org/10.1016/j.bmc.2013.11.006