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Synthesis and cardio protective biological applications of glucodendrimers by H9C2 cell studies.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2014 Jan; Vol. 99, pp. 403-14. Date of Electronic Publication: 2013 Aug 28. - Publication Year :
- 2014
-
Abstract
- Novel glucodendrimers scaffolds containing α-d-glucopyranoside at the surface and triazole as bridging unit have been synthesized. Cardiomyocytes were exposed to normal and high glucose level in the presence and absence of glucodendrimers. Cytotoxicity studies were also carried out and the expression of metalloproteinases mainly MMP-2 and 9 was confirmed with gelatine zymography and RT-PCR gene expression studies. Cardio protective efficiency of the synthesized glucodendrimers against high glucose induced toxicity on mettalloproteinase-2 and 9 and also on H9C2 cell lines revealed that higher generation glucodendrimers 6 and 8 are more effective than the lower generation glucodendrimers.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Cardiotonic Agents chemical synthesis
Cell Line
Cell Survival drug effects
Dendrimers chemical synthesis
Gene Expression drug effects
Glucose antagonists & inhibitors
Glucose pharmacology
Glucosides chemistry
Humans
Matrix Metalloproteinase 2 genetics
Matrix Metalloproteinase 2 metabolism
Matrix Metalloproteinase 9 genetics
Matrix Metalloproteinase 9 metabolism
Myocytes, Cardiac cytology
Myocytes, Cardiac metabolism
Rats
Structure-Activity Relationship
Triazoles chemistry
Cardiotonic Agents pharmacology
Dendrimers pharmacology
Myocytes, Cardiac drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 99
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 24274524
- Full Text :
- https://doi.org/10.1016/j.carbpol.2013.08.040