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Formation of multilayered vesicles from water/organic-solvent (w/o) emulsions: theory and practice.
- Source :
-
Pharmaceutical research [Pharm Res] 1986 Feb; Vol. 3 (1), pp. 23-34. - Publication Year :
- 1986
-
Abstract
- Multilayered liposome (MLV) formation from water/organic-solvent (W/O) emulsions was studied. A fundamental liposome population parameter, the E(ratio), was defined and used to estimate the bilayer number and water spacing in MLV liposomes. MLVs prepared from W/O emulsions have optimum drug entrapment at an emulsion-lipid/emulsion-water ratio of ∼0.33. Drug entrapment is typically 50 to 65% under these optimal conditions.
Details
- Language :
- English
- ISSN :
- 0724-8741
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmaceutical research
- Publication Type :
- Academic Journal
- Accession number :
- 24271353
- Full Text :
- https://doi.org/10.1023/A:1016316730560