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An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction.
- Source :
-
FEBS letters [FEBS Lett] 2014 Jan 03; Vol. 588 (1), pp. 28-34. Date of Electronic Publication: 2013 Nov 20. - Publication Year :
- 2014
-
Abstract
- Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti-IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN-α promoter via various signaling pathways. This study uncovers a novel ability of C protein to block Toll-like receptor (TLR) 7- and TLR9-dependent IFN-α induction, which is specific to plasmacytoid dendritic cells. C protein interacts with a serine/threonine kinase IKKα and inhibits phosphorylation of IRF7. This anti-IFN activity of C protein is shared across genera of the Paramyxovirinae, and thus appears to play an important role in paramyxovirus immune evasion.<br /> (Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Chlorocebus aethiops
Dendritic Cells immunology
Dendritic Cells metabolism
Dendritic Cells virology
HEK293 Cells
Host-Pathogen Interactions immunology
Humans
I-kappa B Kinase genetics
I-kappa B Kinase metabolism
Immunoblotting
Interferon Regulatory Factor-7 genetics
Interferon Regulatory Factor-7 metabolism
Interferon-alpha genetics
Mutation
Paramyxoviridae genetics
Paramyxoviridae metabolism
Paramyxoviridae physiology
Promoter Regions, Genetic genetics
Protein Binding
Transcriptional Activation
Vero Cells
Viral Proteins genetics
Interferon-alpha metabolism
Toll-Like Receptor 7 metabolism
Toll-Like Receptor 9 metabolism
Viral Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 588
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 24269682
- Full Text :
- https://doi.org/10.1016/j.febslet.2013.11.015