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Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice.
- Source :
-
Epilepsy & behavior : E&B [Epilepsy Behav] 2014 Feb; Vol. 31, pp. 276-80. Date of Electronic Publication: 2013 Nov 20. - Publication Year :
- 2014
-
Abstract
- This study was designed to investigate the role of experimental febrile seizures in the induction of generalized clonic seizures and the involvement of heat-sensitive channel TRPV1. Pentylenetetrazol-induced clonic seizure was used as the seizure model, and Trpv1 gene knock-out and wild-type C57/BL6 mice were used as experimental subjects. Electroencephalograph and seizure behavior were recorded for the evaluation of the severity of seizures. Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures. Trpv1 gene deficiency decreased the properties of generalized clonic seizure. The intensity of experimental febrile seizures reduced the threshold to generalized clonic seizure, and Trpv1 gene deficiency decreased the susceptibility to PTZ-induced seizures following early-life hyperthermia challenges in mice.<br /> (© 2013.)
- Subjects :
- Analysis of Variance
Animals
Animals, Newborn
Disease Models, Animal
Dose-Response Relationship, Drug
Electroencephalography
Mice
Mice, Inbred C57BL
Mice, Knockout
TRPV Cation Channels deficiency
Time Factors
Convulsants toxicity
Hyperthermia, Induced
Pentylenetetrazole toxicity
Seizures, Febrile chemically induced
Seizures, Febrile genetics
TRPV Cation Channels metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1525-5069
- Volume :
- 31
- Database :
- MEDLINE
- Journal :
- Epilepsy & behavior : E&B
- Publication Type :
- Academic Journal
- Accession number :
- 24269027
- Full Text :
- https://doi.org/10.1016/j.yebeh.2013.10.022