Prognostic factors in patients with head and neck squamous cell carcinoma with cN3 neck disease: a retrospective case-control study.

Authors :: Jung JH
Roh JL
Lee JH
Kim SB
Lee SW
Choi SH
Nam SY
Kim SY
Source :: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2014 Feb; Vol. 117 (2), pp. 178-85. Date of Electronic Publication: 2013 Nov 22.
Publication Year :: 2014
Abstract: Objective: This study examined prognostic factors in patients with head and neck squamous cell carcinoma with advanced neck disease.<br />Study Design: The records of 191 patients with previously untreated head and neck squamous cell carcinoma and metastatic cervical lymph node (LN) >6 cm (cN, n = 70) and 3.01 to 6 cm (control, n = 121) in the greatest dimension were reviewed. Univariate and multivariate analyses were used to identify factors associated with disease-free survival (DFS) and locoregional control (LRC).<br />Results: In the cN3 group, independent variables for DFS were age, active drinking, LN size, and extranodal extension (P < .05), and that for LRC was age (P = .025). In the control group, independent variables for DFS were tumor location and differentiation and LN bilaterality (P < .05), and that for LRC was LN bilaterality (P = .011).<br />Conclusions: The survival of cN3 patients is affected by host and nodal characteristics including age, drinking, nodal size, and extranodal extension.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)

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